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Articles by Johan Ringlander
Long-read sequencing of rectal swabs in Rwandan children shows links between gut microbiota composition and malnutrition-associated variables
Abstract Gut microbiome composition has been suggested as a factor in the development of malnutrition, which affects one fifth of all children. The microbiome is dependent on environmental and dietary factors, therefore studies on the gut microbiota diversity and relative abundance of bacteria in children with and without malnutrition in different geographical regions are needed.
Novel Long‐Read Sequencing Method for Characterisation of Hepatitis B Transcripts Show High Expression of Chimeric HBV/Human RNA
cccDNA covalently closed circular DNA CHB chronic Hepatitis B HBeAg hepatitis B e antigen HBsAg hepatitis B surface antigen HBV hepatitis B virus HCC hepatocellular carcinoma HDV hepatitis D Virus NGS next-generation sequencing pgRNA pregenomic RNA 1 Background Despite an effective vaccine and antiviral therapy, hepatitis B (HBV) continues to be a significant health concern worldwide, and chronic hepatitis B (CHB) is one of the major causes of cirrhosis and hepatocellular carcinoma (HCC) [1].
Long‐Term Outcome of Chronic Hepatitis B—Histological Score and Viral Genotype Are Important Predictors of Hepatocellular Carcinoma
1 Introduction Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma (HCC) [1, 2]. The course of the infection is highly variable, and the main task for clinicians is to identify patients who are at risk for complications, in order to prevent necroinflammation and HCC by antiviral therapy and identify curable HCC by screening programs.
From the Cytoplasm into the Nucleus-Hepatitis B Virus Travel and Genome Repair
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Hepatitis B virus particles in serum contain minus strand DNA and degraded pregenomic RNA of variable and inverse lengths
The level of hepatitis B virus RNA in the blood has become established as a clinical marker. In this study, we found by quantifying both DNA and RNA in three parts of the HBV genome that particles with HBV RNA are not fundamentally different from those with HBV DNA but represent viruses with incomplete reverse transcription.
Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA
ORIGINAL PAPER Magnus Lindh Corresponding Author E-mail address: magnus.lindh@microbio.gu.se Department of Infectious Diseases, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Corresponding author Magnus Lindh E‐mail: magnus.lindh@microbio.gu.se Address: Guldhedsgatan 10B, 413 46 Gothenburg, Sweden Phone: +46 70‐526 97 46 Search for more papers by this author This article has been accepted for publication and undergone full peer review but has not...
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