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Articles by John B. Schell
Identification of cross-stage, cross-species malaria CD8 + T cell antigens
Abstract A major limitation on the development of a malaria vaccine is the lack of validated T cell epitope targets. Plasmodium falciparum is the most prevalent malaria parasite affecting humans in Africa, whereas Plasmodium vivax is more widespread and is the main species that causes malaria in the Americas and Asia1. P. vivax exclusively infects peripheral-blood reticulocytes, which retain RNA and the capacity for host protein synthesis2. We previously reported that reticulocytes infected with P.
Cellular and Humoral Immune Responses in Mice Immunized with Vaccinia Virus Expressing the SARS-CoV-2 Spike Protein
Jake C. Harbour, Zoe L. Lyski, John B. Schell, Archana Thomas, William B. Messer, Mark K. Slifka and Jeffrey C. Nolz J Immunol June 1, 2021, 206 (11) 2596-2604; DOI: https://doi.org/10.4049/jimmunol.2100054 Key Points VacV-S immunization activates S-specific T cells. Immunization expands T cells that primarily target the S1 domain of spike. Spike-specific IgG-neutralizing Abs form following VacV-S immunization.
Cellular and Humoral Immune Responses in Mice Immunized with Vaccinia Virus Expressing the SARS-CoV-2 Spike Protein
Jake C. Harbour, Zoe L. Lyski, John B. Schell, Archana Thomas, William B. Messer, Mark K. Slifka and Jeffrey C. Nolz J Immunol May 10, 2021, ji2100054; DOI: https://doi.org/10.4049/jimmunol.2100054 KeyPoints VacV-S immunization activates S-specific T cells. Immunization expands T cells that primarily target the S1 domain of spike. Spike-specific IgG-neutralizing Abs form following VacV-S immunization.
Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates
Vaccines and Antiviral Agents Shaheed A. Abdulhaqq, Helen Wu, John B. Schell, Katherine B. Hammond, Jason S. Reed, Alfred W. Legasse, Michael K. Axthelm, Byung S. Park, Aravind Asokan, Klaus Früh, Scott G. Hansen, Louis J. Picker, Jonah B.
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
Three key factors are widely believed to have contributed to the cure of the Berlin patient: (1) the conditioning regimen used for his two transplants, (2) the use of donor cells containing a homozygous HIV-resistant CCR5Δ32 mutation42, and (3) the development of post-transplant GVHD43, which is hypothesized to help clear the HIV reservoir through an as-yet ill-defined GVVR effect. The Boston Patients14, underwent allogeneic HCT and developed GVHD, but received HIV-susceptible donor cells.
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