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Articles by John Buglino
Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence
eLife Assessment In this important study, the authors advance our understanding of copper uptake by chalkophores and their targeted metalloproteins in Mycobacterium tuberculosis. These convincing data demonstrate that chalkophore-acquired copper is solely incorporated into the Mtb bcc:aa3 copper-iron respiratory oxidase under low copper conditions, and that chalkophore-mediated protection of the respiratory chain is critical to Mtb virulence.
Multi ligand sensing by a bacterial histidine kinase through inhibition of dimerization
Abstract Two component systems (TCS) mediate bacterial signal transduction in response to specific environmental conditions. The two components are the sensor kinase (SK), which senses the signal and autophosphorylates on a histidine residue, and a response regulator (RR), which is phosphorylated by the kinase and modifies gene expression.
PacL-organized membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Abstract Metal ion homeostasis is crucial for bacterial pathogens to withstand metal-induced stress during infection. However, the mechanisms underlying bacterial resistance to metal stress remain incompletely understood, particularly how bacteria coordinate responses to simultaneous exposure to multiple metals. Here, we uncover a previously unrecognized mechanism by which Mycobacterium tuberculosis, the causative agent of tuberculosis, orchestrates a coordinated response to multi-metal stress.
Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
Abstract Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis (Mtb). However, it is unknown how intracellular bacterial pathogens such as Mtb maintain respiration during infection despite the chemical effectors of host immunity. Mtb synthesizes diisonitrile lipopeptides that tightly chelate copper, but the role of these chalkophores in host-pathogen interactions is also unknown. We demonstrate that M.
Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
Abstract Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis, but it is unknown how M. tuberculosis and other pathogens maintain respiration during infection. M. tuberculosis synthesizes diisonitrile lipopeptide chalkophores that chelate copper tightly, but their role in host-pathogen interactions is also unknown. We demonstrate that M. tuberculosis chalkophores maintain the function of the heme-copper bcc:aa3 respiratory oxidase under copper limitation.
Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection
Abstract Bacterial pathogens that infect phagocytic cells must deploy mechanisms that sense and neutralize host microbicidal effectors. For Mycobacterium tuberculosis, the causative agent of tuberculosis, these mechanisms allow the bacterium to rapidly adapt from aerosol transmission to initial growth in the lung alveolar macrophage. Here, we identify a branched signaling circuit in M.
Optessa is listed as a Sample Vendor in Gartner Hype Cycle for Supply Chain Planning Technologies, 2020
Priority Matrix for Supply Chain Planning Technologies Optessa was named in the Supply Planning category This inclusion simply validates the importance and benefit that organizations can realize by implementing an intelligent planning and scheduling solution.” — Ashok Erramilli, CEO of Optessa EDMONTON, ALBERTA, CANADA, January 21, 2021 / EINPresswire.com/ -- (“Optessa”), a leading provider of supply planning solutions, today announced that it has been identified as a Sample Vendor in the...
Optessa Selected by Groupe Renault for Advanced Sequencing Solutions
Optessa Intelligent Planning and Scheduling Optessa is delighted and proud to add Renault to its extensive list of Auto OEM clients.
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