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Articles by John Longsworth
How Scale Up Assist Using the BioFlo® 720 Bioreactor Control System Can Help Your Antibody Production Workflow
By Amanda Suttle, John Longsworth, and Ma Sha, Eppendorf, Inc., To scale upstream bioprocesses, an effective scale-up strategy is required to ensure the reproducibility of both cell culture growth and batch yields at large working volumes, ideally with little or no additional optimization. The Constant Power approach is a successful method for matching bioreactor yields at different scales.
Improving Antibody Production Workflow Using The BioFlo 720 Bioreactor Control System
By Amanda Suttle, John Longsworth, and Ma Sha, Eppendorf, Inc., To scale upstream bioprocesses, an effective scale-up strategy is required to ensure the reproducibility of both cell culture growth and batch yields at large working volumes, ideally with little or no additional optimization. The Constant Power approach is a successful method for matching bioreactor yields at different scales.
Dissolved Oxygen Control PID Tuning For Cell Culture Applications
By John Longsworth, Nina Schillings, and Ma Sha Eppendorf bioprocess controllers, such as the BioFlo® 320 Bioreactor Control System, use a proportional– integral–derivative (PID) control mechanism for a variety of processes, including dissolved oxygen (DO) control. The PID control loop mechanism for DO control is essential for optimal bioreactor cell culture. Although the D value is not user adjustable in Eppendorf controllers, the P and I values can be changed.
Caterpillar's Earnings Report Is Coming - Time For A Revisit
Caterpillar Incorporated (CAT) last reported earnings on July 25th. The company raised its guidance for the year, causing its stock to gap up on the news. Since then the stock has moved up to a new all-time high. Caterpillar’s next reporting date of October 24th is rapidly approaching. Is CAT worth buying into at this point? Let’s see what the company’s stock charts and guidance tell us. The monthly chart gives us a nice long-term view of CAT.
Wells Fargo Continues To Stall Out Thanks To These Factors
Some investors continue buying the big bank stocks. But big banks like Wells Fargo Inc. (WFC) face some substantial headwinds. Wells Fargo, in particular, faces some issues that could hold back its stock. The charts and fundamentals for WFC will show why it may not be the best investment right now. WFC’s monthly chart shows that it’s been stuck in a trading range since 2014. The stock did make a new all-time high in January of 2017, but it failed to break out of the trading range.
Tableau Software Races To Its 2015 High Despite Continued Losses
Fall is here, and earnings season is nearly upon us. While the indexes run up to new highs, there are also several stocks moving out of bottoms that provide lower-risk investments. One such stock to consider is Tableau Software (DATA). You can probably guess from the stock symbol what Tableau Software does. The company serves the growing field of data analytics. Its goal is to make data understandable for ordinary people.
Time To Buy Apple? Maybe Not
Apple Inc. (AAPL) experienced a pullback from its all-time highs recently. That's led some to suggest it's a good time to buy Apple on the dip. But is it really the best time to be buying into Apple? For long-term investors, it may not be. Unless you've lived under a rock for the past few decades, you know what Apple does. It manufactures some of the hottest consumer electronics on the market. That includes the iPhone, iPad, and iWatch.
Ambarella's Stock Just Took A Big Dive - Here's What You Need To Know
Sometimes a stock gets hammered badly after an earnings report. It can happen even if the stock had a good or marginal earnings report. Last month Ambarella (AMBA) was one of those stocks. Ambarella beat on revenues last quarter but had lackluster earnings. The stock dropped more than 20%, however, after the earnings were announced. This seems like an extreme sell-off for such a ho-hum report. So why did AMBA drop so badly? And is it a viable investment candidate after this recent drop patterns out?
What President Trump's Twitter Habit Means For Your Portfolio
President Trump's Twitter influence is undeniable. But his comments about individual public companies are also unprecedented. He can cause the stock market to react with just 140 characters. But can that influence alter a stock's trend? What's Trump true impact on the stock market? More importantly, what should investors do to protect themselves? Let's determine that for ourselves by examining some of Trump's most famous tweets about companies and the corresponding stock charts.
This Bottoming Healthcare Stock Just Narrowed Its Guidance
When we last looked at CVS Health (CVS) in April, it was attempting to bottom after correcting in 2016. The stock hasn't moved much since then, but the company did release some new earnings recently. So could CVS be set for a turnaround? Let's take a look at the charts and recent earnings report to find out. CVS Health's primary business is pharmacy services. The company operates over 9,600 pharmacies around the country. The company also provides pharmacy services to the long-term care market.
MASI Beat Estimates, Then Dropped Like A Rock
When we last looked at Masimo Corporation (MASI) back on May 9th, it had just dropped steeply after the release of its first quarter earnings report. Since then it ran back up during June and July, but just dropped strongly again after reporting its second quarter earnings. One has to wonder if this is the start of a top and a stronger move down for MASI. A thorough analysis of the charts and last earnings report can tell us what to expect though. First, a quick refresher about what Masimo does.
Caterpillar Just Raised Its Guidance
We last took a look at Caterpillar Inc. (CAT) back in early May. At the time CAT was moving up nicely out of an intermediate-term bottom. It had started to climb more rapidly thanks to a strong earnings report. At the time, Caterpillar indicated that it expected to continue to perform strongly this quarter. It recently reported for the second quarter on July 25th. So how well has Caterpillar performed since May? Let’s take a look at the stock charts and earnings report to find out.
Myriad Genetics' Stock Is Starting To Make A Run
Healthcare’s been in the news a lot lately thanks to the Republicans’ efforts at healthcare reform. There are several bottoming heathcare and biotech stocks that could benefit from these efforts. One of those companies with potential is Myriad Genetics (MYGN). Myriad creates genetic tests to screen for genetic cancer risk and other diseases. It’s currently coming out of a bottom and has the potential to continue moving up if it can capitalize on this growing market.
Virtusa Corp. Is Completing Its Bottom, Now It Could Break Out
Several technology stocks have been on a tear lately. Many are over-speculated and near all-time highs. Some, however, are just coming out of bottoms and are ripe for an intermediate to long-term trade. Virtusa (VRTU) could be one of those companies. Virtusa provides IT consulting services around the globe. It services a diverse set of industries including banking, financial services, insurance, healthcare, telecom, and media.
Looking To Diversify Your Portfolio With A Foreign Technology Stock? Consider 58.Com
It’s always a bit of a challenge to find promising foreign stocks to invest in. A technology company out of China called 58.com (WUBA) shows some promise though. It’s recovered from a long-term downtrend and started climbing earlier this year. But can it continue to move up? A check of the stock chart and fundamentals can provide some clues.
Sorry, Financial News Media, Oil's Not In A Bear Market Yet
U.S. crude oil prices experienced a large 2% decline on 6/20/17, dropping to seven-month lows. The financial news media was quick to proclaim that oil had entered "bear market territory." But is oil really in a bear market? The charts say otherwise. There are several varying definitions of what a bear market is. It's clearly a reversal from an upward trend to a downward one for an extended period. But the definition of specifically when that occurs varies.
House Republicans Just Passed The Financial CHOICE Act. Here's What It Means For You
It was also almost 10 years ago that the major stock indexes started a bear market due the great financial crisis of 2008-2009. Some of the legacies of that time still impact us today. One of the legacies of the financial crisis is the Dodd-Frank Wall Street Reform and Consumer Protection Act. The goal of this law was to ensure that the conditions that lead to the financial crisis never happened again. Figure 1: Monthly chart of the S&P 500 during the financial crisis of 2008-2009.
Small Caps Are Lagging Behind The Broader Market - Here's How To Trade Them
The markets have been rising well over the past few weeks. The Nasdaq, in particular, has done extremely well thanks to the strong performance of technology stocks. But small caps, for the most part, have been lagging behind this year. That makes it harder for small cap investors to find good trading candidates. It's been especially hard on investors that like small cap ETFs. There are still opportunities in small caps though, if you know where to look for them.
Progressive Corporation Has Progressed To An All-Time High And Has Further To Climb
Progressive Corporation's stock (NYSE:PGR) has been on a tear over the past few months. In fact, it just hit a new all-time high last week. But can Progressive continue its strong climb? The company's stock chart and financial statements can help us determine what to expect. Just about everyone knows who Progressive is, thanks to their humorous commercials. Most people have seen Flo in action on TV. Progressive started selling affordable auto insurance back in 1937.
Are High Frequency Traders Good Or Bad For The Markets?
On old CNBC clip popped up in my YouTube feed recently. It piqued my interest because the video rehashed the (now) old debate of whether High Frequency Traders (HFTs) are good for the markets. Briefly, this old segment of CNBC's Power Lunch dealt in particular with Michael Lewis' book Flash Boys. The crux of Lewis' argument is that the faster trades of HFTs allow them to front-run and scalp retail trader's orders, which are executed at a much slower speed.
More Bad News For United Airlines, But Traders Don't Seem To Care
There's more bad press for embattled United Airlines (NYSE:UAL). This time, a United Crew forced a passenger to pee in a cup. It's the latest episode in a rough couple of months for United. None of this negative press seems to bother traders though, since United's stock continues to climb. In this latest incident, Nurse Nicole Harper had to use a restroom while her plane was beginning its descent back on April 10th. Passengers were told to stay in their seats per standard procedure during a descent.
Fortinet Just Completed Its Bottom - What's Next?
If you're looking to add a technology stock to add to your portfolio you may want to consider Fortinet Incorporated (NASDAQ:FTNT). FTNT is completing a long-term bottom and is poised to make a run at its all-time high. It has substantial room to move up and a lot of profit potential. Fortinet makes cyber security products for server and enterprise applications. There's certainly a lot of demand for effective products in this field.
Masimo Had A Good Run... Is It Time To Sell?
Masimo Corp. (NASDAQ:MASI) has had a good run going this year. I have to admit that I had a lot of fun trading this stock as a paper trade. I bought it in my simulator in November and sold out in February at about $85. But MASI's financials have started to stagnate, and it missed on its May 3rd earnings report. That caused it to drop like a rock on May 4th. So is MASI now a buy, hold or sell? Let's look at the data and see what it tells us. First, it helps to understand exactly what Masimo does.
Caterpillar Could Be Set To Break Out Of Its Slump... Here's Why
Caterpillar Inc. (NYSE:CAT) just broke out of its sideways pattern on strong earnings news. It's experiencing a turnaround in its construction and related businesses. That turnaround is helping to fuel improving financials for CAT. So let's take a closer look at CAT to see if it's a worthwhile investment right now. Caterpillar is a well-known world leader in the manufacturing of construction and mining equipment. It also makes gas engines and electric turbines.
VMware Is Poised To Continue Its Run
VMWare, Incorporated (NYSE:VMW) stock has run up strongly since bottoming in early 2016. Right now it's in a resting pattern as it builds strength. It has plenty of room to run though, and great fundamentals to power that run. It's a technology stock that's worth consideration. Let's take a closer look at it. VMware, Inc. is a subsidiary of Dell Technologies. It was part of EMC until 2016, when Dell took EMC over. There was a lot of concern at the time about the future of the company.
Buy McDonald's At An All-Time High? Sounds Like A Recipe For Disaster
A recent article on CNBC suggests that McDonald's Corporation (NYSE:MCD) could extend its run after hitting a new all-time high. But a closer look at McDonald's financials show that it isn't as promising of an investment as they suggest. Why Some Analysts Like MCD The analysts in the CNBC article suggest that the fundamentals are lining up for a continued MCD run. They said that changes to the menu, such as the move to fresh beef, will lead to higher profits for the company.
Remember United Continental's Big Stock Drop Last Week? It Never Actually Happened
The major air carrier United Continental Holdings, Inc. (NYSE:UAL) made headlines last week when its staff had passenger Dr. David Dao forcibly removed from a flight. The video of the incident sparked outrage throughout the world. At the time several news agencies claimed that the public uproar had caused United's stock to drop. TIME claimed that UAL plummeted after the video went viral. CNN.com wrote that the stock fell 4% and lost $1 billion in market value.
How JPMorgan Chase Can Avoid A Stock Top
JPMorgan Chase & Co. (NYSE:JPM) is a well-known corporation that provides investment and financial services to individuals, governments, and businesses around the world. Its stock has been on a tear lately thanks to the Trump rally. It even made a new all-time high earlier this year. But lately it's been moving sideways, and even sliding down a little within that sideways action. That's largely because JPMorgan Chase's revenues have been largely flat, which puts the stock at risk of a top.
Looking For A Healthcare Stock With Potential? Consider CVS
If you're looking for a bottoming healthcare stock with a lot of potentials, take a look at CVS Health Corporation (NYSE:CVS). CVS started forming an intermediate-term bottom back in November of 2016. This stock has a lot of upside potential for anyone looking to add healthcare stocks to their portfolio. CVS is a healthcare provider with 9,600 pharmacy stores around the country.
The Dow Is Too Heavily Speculated - Stop Buying Fast-Running Stocks
The Trump rally has taken the Dow Jones Industrial Average into the stratosphere. It seems like everyday the Dow is breaking a new milestone. This has excited legions of new investors to put their money into Dow-listed stocks. They're hoping to cash in on quick-running Dow components. Some Dow Components are Running on Fumes This strategy is ill-advised though. Several Dow stocks are moving up on pure speculation, way beyond their fundamental values.
How To Take Advantage Of The Trump Energy Policy To Find Investment Opportunities
The Donald Trump presidency is finally a reality. This begs the question, which stocks will now outperform during the Trump era? One possibility is the energy sector, and oil stocks in particular. How a Trump Presidency Could Affect the Oil Industry It's no secret that Trump is a big supporter of the oil industry.
Follow This Piece Of Economic Data To Avoid Bear Markets
Are you concerned about avoiding the next true bear market? Want to preserve your capital before the market turns down again? While it's impossible to tell exactly when the next big bear market will start, there are a few fundamental indicators that can help. One of those indicators is the U.S. unemployment rate. The Relationship Between the Stock Market and the Unemployment Rate The stock market and the unemployment rate have an inverse relationship.
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