Abstract Injury to the cytoskeleton enhances the regenerative potential of axons. This response requires dual leucine zipper kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration and degeneration. The damage and repair aspects of this response are reminiscent of other cellular homeostatic systems, suggesting that a cytoskeletal homeostatic system may exist. In this study, we propose a framework for understanding DLK mediated neuronal cytoskeletal homeostasis.
