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As symptomatic brain metastases are devastating for patients, impairing quality of life (QoL), 13 we have performed a randomized study to investigate whether PCI reduces the proportion of patients with symptomatic brain metastases.
Patients with stage III NSCLC—staged with a contrast-enhanced brain computed tomography or magnetic resonance imaging—were randomly assigned to either observation or PCI after concurrent/sequential chemoradiotherapy with or without surgery.
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