John Neff
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Articles by John Neff
Cysteine Reactivity Profiling Identifies Host Regulators of Mycobacterium tuberculosis Replication in Human Macrophages
Cite Jump to ExpandCollapse ArticleJanuary 27, 2026 Cysteine Reactivity Profiling Identifies Host Regulators of Mycobacterium tuberculosis Replication in Human Macrophages Click to copy article linkArticle link copied! John K. Neff John K. Neff Department of Internal Medicine, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390, United States Department of Microbiology, University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75390, United States Kristen E.
Nissan to double Nismo lineup and may develop exclusive Nismo sports car
While Nissan's struggles as of late have been well documented, the Japanese automaker also has a few wins it can celebrate. The new Leaf may be the best value in the entire electric car segment (it won Car of the Year in our annual Buzz Awards). The new plug-in hybrid Rogue came free from Mitsubishi. And they've got Roush tuning the Nissan Frontier now.
Porsche 718 Boxster and Cayman to offer gas engines despite EV development
Electric versions of the Porsche 718 Boxster and Cayman have been under development for a long time. The first time we mentioned them here on TopSpeed was back in early 2021. After a long gestation period and winding down production of the current gas-powered models, Porsche is on schedule to debut its new electric sports cars sometime next year.
Nissan's Nismo Expansion: Doubling Models & Teasing Standalone Sports Car
While Nissan's struggles as of late have been well documented, the Japanese automaker also has a few wins it can celebrate. The new Leaf may be the best value in the entire electric car segment (it won Car of the Year in our annual Buzz Awards). The new plug-in hybrid Rogue came free from Mitsubishi. And they've got Roush tuning the Nissan Frontier now.
Porsche's Shocking Reversal: 718 Boxster And Cayman Could Get Gas Engines, Too
Electric versions of the Porsche 718 Boxster and Cayman have been under development for a long time. The first time we mentioned them here on TopSpeed was back in early 2021. After a long gestation period and winding down production of the current gas-powered models, Porsche is on schedule to debut its new electric sports cars sometime next year.
Tesla Sales Plummet 23% in November Despite Cheaper Model Y and 3
According to sales data from Cox, sales of Tesla vehicles fell to 39,800 units in November. That marks a 23-percent fall from the same month last year when Tesla sold 51,513 units and the lowest monthly total since January 2022. This significant sales fall has occurred despite the EV manufacturer launching cheaper versions of its Model Y and Model 3 in October.
Rimac's Solid-State Battery Tech To Debut in Bugatti Model
Rimac may use a Bugatti model for the first application of its high-tech solid-state battery (SSB), according to Nurdin Pitarevic, the second-highest-ranking executive at the automaker behind CEO Mate Rimac. Pitarevic told Autocar his "wish would be" that a new mid-volume Bugatti model is the first product to use the company's revolutionary SSB.
Fiat's Tiny Topolino EV is Coming to America: Crazy or Genius Move?
Stellantis has announced it will sell the tiny electric Fiat Topolino city car in the U.S. Fiat CEO Olivier François confirmed the news at Art Week Miami where he was debuting a one-of-one Topolino art car. The timing of the launch, as well as details such as pricing and U.S. specifications, will come next year. The Topolino ("little mouse" in Italian) is a strange little thing designed for use in dense European cities.
Genesis G90 Gets One Of The Oddest Recalls We've Seen
Genesis has become quite successful as an upstart luxury automaker, and much of that has to do with its beautiful designs. Its entire lineup of cars and SUVs shares a boldly attractive visual language that looks good from every angle and in every light. Its choice of paint colors, however, has proven to be a problem. The Genesis G90 is being recalled over its Highway Drive Assist (HDA) system, which under normal operation allows for low-level autonomous driving.
Michigan Ranked Best State For Driver Safety In 2025 Study
If we had 50 guesses to tell you which state in the U.S. plus the District of Columbia has the best drivers with the least accidents, we would not have used one of those guesses to say Michigan. And yet, it's true! Two studies performed this year by insurance companies who keep records on this sort of thing back up Michigan's safety record, which to some (like us) seemed unlikely at first glance. Studies from Lending Tree and Insurify both testify to this fact.
Tesla Model Y Ranked Worst In Reliability By German TÜV Report
The Tesla name has never been synonymous with build quality, but a damning report out of Germany just comes right out and says it: the Model Y has terrible reliability. Technischer Überwachungsverein of Germany, or TÜV for short, has published its 2026 reliability report, which says the Tesla Model Y has a 17.3-percent defect rate for cars 2 to 3 years old. That's the worst reliability rating TÜV has seen in the last 10 years.
Ford CEO Hints at Possible Return of Sedans, Reveals Reason for Past Cancellation
Well-known automotive influencer Forrest Jones recently published an interview with Jim Farley in which the Ford CEO asked if the host's audience would like a rear-wheel-drive, high-performance, affordable electric sedan based on the same $30,000 skunkworks platform being developed right now for an electric truck. According to Farley, a sedan's silhouette is aerodynamically clean, which would lend itself well to electrification.
Second-Gen Kia Seltos SUV Teased Ahead of December 10 Reveal
Kia India has released the first teaser video and images of the second-generation Seltos SUV ahead of its official reveal on December 10. The Seltos is a truly global product, having first launched in 2019 before it arrived in the U.S. for the 2021 model year. It makes sense these teasers are coming out of India, though, as that country buys more Seltos SUVs than anywhere else in the world.
Mercedes-Benz CLA Takes Aim At Tesla Model 3 With Competitive Pricing And Range
Mercedes-Benz has announced pricing and official EPA range estimates for its all-new 2026 CLA electric car, and there's one company in particular that should be worried. The new CLA will start from $47,250 and have an EPA-rated range of 374 miles when it begins arriving at dealerships in early 2026. Those figures make the new CLA a direct competitor of the second most popular electric car sold in the U.S., the Tesla Model 3.
Jeep Avenger SUV Debuts In Brazil With Iconic Glass-Breaking Stunt
Jeep has resurrected one of its most famous stunts to welcome its Avenger SUV to Brazil. The automaker celebrated the arrival of its small SUV to the country recently by driving it through a plate-glass window on stage at the 2025 São Paulo Motor Show.
Gordon Murray S1 LM Supercar Breaks Auction Record at $20.6 Million
The Las Vegas Formula One Grand Prix this past weekend played host to a special vehicle auction that saw the record broken for the most expensive new car ever sold at auction, excluding vehicles sold for charity. The object of everyone's bidding was the Gordon Murray S1 LM supercar, and when the final gavel fell, its new owner was $20.6 million poorer.
Genesis Magma GT: The Luxury Supercar Taking On The Corvette
Genesis has built a reputation for boldness in its relatively short lifetime, and it reinforced that impression this week when it debuted the Magma GT concept, a mid-engine supercar it intends to build and race. That's right, the Magma GT is not a styling exercise or skunk works project; it sits atop the company's product roadmap as its future halo car and apex motorsport entrant. The Magma GT wasn't the only thing Genesis revealed this week.
Porsche Cayenne EV Stuns In Drag Rage With 918 Spyder, Schools Tesla In The Process
Ever since the Tesla Model S debuted in 2012, we've witnessed electric vehicles break the laws of physics and outperform the day's very best vehicles with internal combustion engines. This one, though, warps our brains. During the world premiere video of the new Cayenne Electric, Porsche demonstrated its performance by staging a drag race between it and the brand's legendary 918 Spyder, one of the first hypercars ever built.
New RAV4 Hybrid Prices Revealed: Is Toyota's Best-Seller Still a Bargain?
We now have pricing for the totally redesigned sixth-generation Toyota RAV4 for 2026. With the popular SUV's switch to an all-hybrid lineup, the base price for a front-wheel-drive (FWD) RAV4 Hybrid LE has risen to $31,900. Last year's base model, a gas-powered RAV4, started at $29,800, which is $2,100 less than the new one. Considering it's an all-new SUV with upgrades across the board, the price adjustment strikes us as reasonable.
Help Us Identify These Clay Models At Ford’s New World Headquarters
Ford is celebrating the grand opening of its new world headquarters. The new facility encompasses 2.1 million square feet of space and will house 4,000 employees when it's fully completed in 2027.
Jeep’s Recalling The Hybrid SUVs For An Even Crazier Reason
It's been a terrible month for owners of the Jeep Wrangler 4xe and Grand Cherokee 4xe. These people thought they were buying a sophisticated plug-in hybrid that would make their lives easier, but the last few weeks have been anything but. The first issue came in mid-October when Jeep issued an over-the-air (OTA) update that rendered their vehicles inoperable. In slang terms, they were bricked.
Ancient Monument Damaged In Failed SUV Stunt: What Went Wrong?
A publicity stunt in China went horribly wrong when an SUV slid backwards on the Tianmen Mountain "Sky Ladder" steps and smashed into guardrails, damaging the ancient monument. Nobody was injured, thankfully, but bystanders, who were not allowed on the steps while the event was going on, captured video of the moment the SUV ran into trouble. The monument, located in Tianmen Mountain National Park, is a stone staircase comprised of 999 steps.
McLaren to Launch SUV in 2028, Competing with Lamborghini and Ferrari
Lamborghini and Ferrari thought they were safe from competing with McLaren when they each launched their first SUVs. Lamborghini made the first move with generous parts sharing from its corporate cousins when it launched the Urus in 2018. Ferrari tried holding out, but ceded to its own financial interests when it began selling the Purosangue in 2023. McLaren was supposed to be different, and said as much in 2018 when the president of McLaren North America publicly commented, "...
Ford Racing's Mystery Car: Is It The GT Supercar Reborn?
Ford Performance was rebranded as Ford Racing in September, and this January 15th, the newly minted performance and racing division is having its coming out party at the company's historically significant Michigan Central Station. Every single car in Ford's motorsport arsenal will be on display, including the first pair of Red Bull Formula 1 cars to be powered by Ford. But that's not even the biggest news coming from this event.
Chevy Corvette C8 Overtakes C7 in Sales, Becoming Fifth Best-Selling Generation
The mid-engine Chevrolet Corvette C8 has overtaken its predecessor, the front-engine C7, in sales after six years on the market. The C7, which was the seventh and final generation of front-engine Corvettes, sold a grand total of 189,507 units in its half a dozen years on sale. The C8, meanwhile, has racked up 194,969 sales in the same amount of time, beating the C7 by 5,462 units. The C8 won't stop there, either.
Tesla Introduces $60/day Rental Program with Unlimited Mileage and Free Supercharging
Tesla has introduced a rental program for customers that offers the use of one of its cars for three to seven days starting at just $60 per day, plus taxes and fees. Along with the cheap pricing, Tesla is offering many perks to go along with your rental. These include unlimited mileage, free Supercharging, and the use of Full Self-Driving (Supervised) for the rental's duration. Perhaps the only limit is that you can't leave the state in which you rented the Tesla.
The F-150 Lightning Could Be The First Casualty Of Ford’s EV Reset
According to the Wall Street Journal, Ford is actively discussing ending production of the electric version of its F-150 pickup truck. The newspaper cites only "people familiar with the matter" and asserts no final decision has been made, but there are clear signals this once-important EV may be in trouble. Currently, the F-150 Lightning is the best-selling electric pickup truck on the market.
Toyota Tundra's V-8 Hybrid Powertrain: Raptor's Worst Nightmare Rumored
A short quote from Takashi Uehara, Toyota's president of powertrains, has given rise to the rumor that the company could well be planning to build a desert runner-style, off-road, high-performance version of the Tundra to rival the Ford F-150 Raptor, or perhaps even the Raptor R.
Jeep's Electric Nightmare: 320,000 Vehicles At Risk Af Spontaneous Combustion
Jeep has issued a massive recall for certain Wrangler 4xe and Grand Cherokee 4xe plug-in hybrid models over a risk their battery packs may catch fire while parked or driven. The company is advising all owners affected by the recall to park their Jeeps outside and away from any structures until they've been fixed. They should also refrain from charging their vehicles, as the risk of fire is greater with a fully charged battery.
Ram SRT Street Truck: Evidence Points To High-Performance Model
The coming months will bring us not one, but two new SRT model debuts from Ram, according to Antonio Filosa. The Stellantis CEO made the comment to Wall Street analysts last Thursday, which has set off speculation as to what the two vehicles might be.The first is most likely the return of the Ram 1500 TRX, this time with SRT branding.
SRT Lives! Ram Is Cooking Up Two Performance Models, One Probably Built For The Streets
The coming months will bring us not one, but two new SRT model debuts from Ram, according to Antonio Filosa. The Stellantis CEO made the comment to Wall Street analysts last Thursday, which has set off speculation as to what the two vehicles might be. The first is most likely the return of the Ram 1500 TRX, this time with SRT branding.
Toyota Corolla Hybrid Will Use New 1.5-Liter Engine For Improved Fuel Efficiency
The Corolla Concept from Toyota was one of the surprise hits of this year's Japan Mobility Show. No one was expecting such a far-out design concept for the next generation of Toyota's most popular vehicle of all time. While most were focused on the car's futuristic exterior, Car and Driver spoke with the man at Toyota responsible for powertrains, Takashi Uehara, about the next Corolla's hybrid system.
YouTubers Transform Hyundai Ioniq 9 Into Off-Roader For SEMA
Hyundai has unveiled an off-road version of its three-row electric family SUV for this year's SEMA show in Las Vegas. The modified Ioniq 9 was created in collaboration with YouTube personalities Jeremiah Burton and Zach Jobe, who run a channel called BigTime on the platform. With nearly 1.8 million subscribers and most of their videos attracting hundreds of thousands, if not millions of views. Hyundai picked a popular pair of influencers to work with. The changes to the Ioniq 9 are actually minimal.
Subaru Unveils Electric And Gas-Powered STI Concept Cars At Japan Mobility Show
Subaru has pulled the wraps off its pair of STI-themed concept cars at the 2025 Japan Mobility Show. One is an electric vehicle called the Performance-E STI concept, while the other, called the Performance-B STI concept, is gas-powered.
Japan Mobility Show
Location Tokyo Big Sight Dates October 30 - November 9, 2025 Address 3 Chome-11-1 Ariake, Koto City, Tokyo 135-0063, Japan The Japan Mobility Show replaces the Tokyo Motor Show as the premiere automotive event in Japan. The event brings together automakers, tech companies, and designers from around the globe to showcase the latest in consumer cars, electric vehicles, autonomous technology, smart infrastructure, and beyond.
Saleen's New Supercar: You Won't Believe Who's Designing It!
What do you think of when you hear the name "Saleen"? We think of the Ford Mustang – lots of Mustangs, in fact. A certain high-performance Ford Explorer from the '90s also comes to mind. And, of course, there's the S7 supercar, a bonafide Amercan supercar, if not early hypercar. Today, Saleen is working on a follow-up to the S7 called the S11. The new supercar has made its public debut at LeMay – America's Car Museum in Tacoma, Washington.
Ford Patent Puts Facial Recognition To Good Use — For Dogs
Not being able to find your pet is one of those gut-wrenching feelings only reunification can fix. Fortunately, Ford has filed a patent to use the technology in its cars to help owners and their pets find each other when the latter wanders off. The patent, which was filed on April 18, 2024 but only recently published, describes a system that uses a car's exterior cameras to capture images or videos of dogs that pass it.
Ford Pauses F-150 Lightning Production Amid Aluminum Shortage
In the wake of a factory fire at one of Ford's biggest aluminum suppliers, the automaker has decided to stop producing its F-150 Lightning electric pickup truck. At least for now. As it begins to ramp up its truck production following the fire at a Novelis aluminum plant on September 16, Ford will instead boost the number of gas-powered and hybrid F-150 models it builds to make up for the lost production.
Alfa Romeo's Shocking U-Turn: Gas-Powered Quadrifoglio Models Return!
What a difference (not even) a year makes. Instead of continuing on a path towards full electrification by launching a new generation of the Giulia and Stelvio this year, Alfa Romeo is instead going to keep the current gas-powered models around until 2027 and bring back their high-performance Quadrifoglio models. Former Stellantis CEO Carlos Tavares had most of the automaker's brands on the fast path towards full electrification, but all that changed when he resigned in December 2025.
Infiniti's Secret GT-R Powered QX80 R-Spec: The Ultimate SEMA Surprise?
Infiniti has released a pair of teaser images and a brief press release about the vehicle it will debut at this year's Specialty Equipment Manufacturer Association (SEMA) Show in Las Vegas. Called the QX80 R-Spec, it appears to be an ultra-high-performance version of the brand's extra-large SUV that may be powered by the engine from the Nissan GT-R.
Toyota’s New ‘Baby’ Land Cruiser Off-Roader Is The Latest Forbidden Fruit In The U.S.
After months, if not years, of speculation, Toyota has finally unveiled its "baby" Land Cruiser. The Toyota FJ is a pint-sized off-roader that will go on sale in Japan in mid-2026. It's destined for other Asian markets, as well as the Middle East, but unfortunately for us, not the U.S. or Europe. Looking for all the world like a Land Cruiser 250 that's been left in the dryer too long, the new FJ is smaller in every dimension yet still has excellent approach and departure angles from the look of it.
Porsche Patents Innovative W12 Engine Design With Three Cylinder Banks
Porsche has filed a patent for a new W12 engine it's developing that employs a unique configuration. The Volkswagen Group is no stranger to oddly configured W12 engines, of course. The iconic Bentley 6.0-liter W12 ended production earlier this year after serving smiles for decades. Whereas that W12 was created by marrying two narrow-angle VR6 engines from Volkswagen at the crankshaft, Porsche's new design features three banks of cylinders.
Cadillac CT4 And CT5 Production To End in 2026, Future Model To Be ICE-Powered
The 2026 model year will be the last for the Cadillac CT4 and CT5, including their high-performance Blackwing models. A replacement for the CT5, however, will arrive at some point in the future and be powered by an internal combustion engine. The news comes from Cadillac V-Club, an enthusiast website that published a letter it claims came from the desk of John Roth, Vice President, Global Cadillac.
Subaru Teases Electric And Gas-Powered STI Concepts for Japan Mobility Show
The steady march of teasers being released ahead of this year's Japan Mobility Show continues. Following Mitsubishi's announcement of an electric crossover SUV concept, Toyota's tease of a new Corolla concept, and Mazda's glimpse of a new coupe-like sedan, it's Subaru's turn to show us what it's got. And we're happy to report it's got something good. Subaru will be showing not one, but two STI-themed concept cars at this year's Japan Mobility Show.
Jeep's Game-Changing Move: Grand Wagoneer Goes Electric for 2026
The 2026 Jeep Grand Wagoneer has arrived, and with it comes a new extended-range electric powertrain that may change the game. Jeep's biggest SUV has also received a refreshed design, substantial price reductions, and an easier-to-understand lineup thanks to the brand killing off the former non-Grand Wagoneer model. The 2026 Grand Wagoneer will also wear Jeep branding for the first time.
The 2026 Toyota RAV4 Debuts New Infotainment System with Impressive Features
While Toyota is known for building safe, reliable, efficient automobiles, it has never been known for the software in its vehicles. Toyota infotainment systems over the years have been average at best, never once being the fastest, slickest, or offering the biggest screens. That may change with the introduction of the all-new 2026 Toyota RAV4, which will come with the new Toyota Audio Multimedia System.
A Black Swan Song For Volvo's Iconic Wagon
The final Volvo V90 has been built at the company's manufacturing facility in Torslanda, Sweden. Fittingly, the car is finished in black. The ebony station wagon isn't headed to a collector's private collection, though. In fact, it isn't being sold at all. Instead, the company is keeping the car for itself and placing it in the Volvo Heritage Collection, which can be viewed at the World of Volvo experience center in Gothenburg.
America's Cheapest Long-Range EV Is Back With A Vengeance
Chevrolet hosted an event on Wednesday, during which it debuted the sort-of-all-new 2027 Bolt. The prior Bolt was produced from 2017 to 2023 and had a reputation as the most affordable long-range EV you could buy in the U.S. It's taken a few years off so that Chevrolet could upgrade its battery, among other things, and it returns for 2027 with largely the same design and packaging as the previous Bolt EUV. Sorry folks, the original Bolt hatchback appears to be gone for good.
Toyota Partners with Sumitomo Metal to Develop Solid-State Batteries for EVs
Toyota has announced it's just two to three years away from launching EVs with solid-state batteries (SSB) thanks in part to a new agreement with Sumitomo Metal Mining. The two companies have been working together since 2021 to develop more durable cathode materials that often break down with repeated charging and discharging cycles, and they've made a breakthrough.
Iconic Hamster-Mobile Faces Extinction
Kia has confirmed the 2025 model year of its funky and fun Soul hatchback will be its last. On sale for the last 16 years through three generations of design, the Soul has been an important cornerstone in Kia's success here in North America. Unfortunately, its sales have fallen precipitously since the debut of the third-generation Soul in 2019. Where the Soul's annual sales were once a six-digit number, it struggled to exceed 50,000 sales in 2024, and the pace so far in 2025 has been even worse.
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