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Articles by Jonas E. Malmsten
Trial emulation for validating the clinical efficacy of a foundational AI model in embryo selection
Abstract AI models for embryo selection often rely on correlational metrics that ignore clinical confounders. We present a target trial emulation framework to approximate causal effects for a foundational AI model, FEMI, for non-invasive embryo assessment using multi-center trial emulation (n = 4674).
A foundational model for in vitro fertilization trained on 18 million time-lapse images - Nature Communications
Abstract Embryo assessment in in vitro fertilization (IVF) involves multiple tasks—including ploidy prediction, quality scoring, component segmentation, embryo identification, and timing of developmental milestones. Existing methods address these tasks individually, leading to inefficiencies due to high costs and lack of standardization. Here, we introduce FEMI (Foundational IVF Model for Imaging), a foundation model trained on approximately 18 million time-lapse embryo images.
Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging - Nature Communications
Abstract Assessing fertilized human embryos is crucial for in vitro fertilization, a task being revolutionized by artificial intelligence. Existing models used for embryo quality assessment and ploidy detection could be significantly improved by effectively utilizing time-lapse imaging to identify critical developmental time points for maximizing prediction accuracy. Addressing this, we develop and compare various embryo ploidy status prediction models across distinct embryo development stages.
Accumulation of per- and polyfluoroalkyl substances (PFAS) in a terrestrial food web
Abstract Per- and polyfluoroalkyl substances (PFAS) are synthetic organofluorine chemical compounds that are broadly used in amongst others aqueous firefighting foam, cosmetics, textiles, carpets, coatings, plastics, and ski wax. Their chemical properties make them persistent organic pollutants that are potential bioaccumulative and toxic. Most studies on PFAS have been performed in groundwater, surface water and aquatic biota. Our knowledge on the terrestrial fate of PFAS is therefore limited.
Divergence in parturition timing and vegetation onset in a large herbivore-differences along a latitudinal gradient
1. Introduction For species with large geographical distributions, flexibility in life cycle events may be central for adapting to changing forage conditions. Northern environments have a short growing season. The timing of parturition should coincide with resource availability and peaks in quality to maximize animals' fitness [1,2] to meet short (e.g. lactation) and long-term (e.g. building fat reserves) energy demands during spring and summer [3,4].
Health and zoonotic Infections of snow leopards Panthera unica in the South Gobi desert of Mongolia
Introduction While the overall decrease in biodiversity is often attributed to environmental changes such as land clearing, habitat d estruction, feral pests and climate change, emerging infectious disease can also act as a primary or contributory cause [1 Tompkins DM, Carver S, Jones ME, et al. Emerging infectious diseases of wildlife: a critical perspective. Trends Parasitol. 2015 Feb 20;31(4):149–159. PubMed PMID: 25709109.[Web of Science ®] , [Google Scholar]–3 Woolhouse ME, Gowtage-Sequeria S.
Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization
Abstract Visual morphology assessment is routinely used for evaluating of embryo quality and selecting human blastocysts for transfer after in vitro fertilization (IVF). However, the assessment produces different results between embryologists and as a result, the success rate of IVF remains low. To overcome uncertainties in embryo quality, multiple embryos are often implanted resulting in undesired multiple pregnancies and complications.
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