The authors have declared no competing interest. This study was supported by the National Institutes of Health under grants R01NS100849-01A1 and 1RF1NS127809-01A1. The National Institute of Neurological Disorders and Stroke (NINDS) was not involved in the study's design, data collection, analysis, interpretation, or manuscript preparation. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.