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Understanding genetic variation is fundamental in the study of human evolution and genetic diseases. The first human reference genome, revealed by the Human Genome Project, allowed geneticists to study genetic variation between individuals at the genome level, leading to rapid advancement in targeted and whole-genome sequencing technologies (1–7).
Anaesthesia induction and maintenance will be performed according to the standard operating procedure of the Asan Medical Center [11]. Cefoxitin will be administered before the skin incision. We shall randomly allocate patients to the study group (administration of cefoxitin via TCI method) and the control group (administration of cefoxitin using standard method). We chose standard administration method as the comparator because it is the administration method currently used around the world.
BACKGROUND: Lymphovascular and perineural invasion are well-known negative prognostic indicators in rectal cancer, but previous studies on their significance are not consistent. OBJECTIVE: This study assessed the prognostic value of lymphovascular and perineural invasion in rectal cancer patients who received preoperative chemoradiotherapy followed by curative resection. DESIGN: This is a retrospective analysis. SETTING: This study was performed at a tertiary cancer center.
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