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Jongmin Sim

As seen in: Nature, Journal of Clinical Pathology, OMICS Publishing Group
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Articles by Jongmin Sim

Lobular carcinoma as a spectrum: resolving the gray zone between morphology, E-cadherin, and CDH1

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By You-Na Sung, Jongmin Sim, Jeong-An Gim, Taesung Jeon, Ji-Yun Lee, Jaewon Oh, Seung Pil Jung, Kyong Hwa Park, Aeree Kim, Hyangsoon Lim
| Nature Verified
Abstract Invasive lobular carcinoma (ILC) is characterized by E-cadherin loss resulting from CDH1 inactivation, but discordance among morphology, immunohistochemistry (IHC), and molecular findings can complicate diagnosis. We integrated histology, IHC, DNA sequencing, and whole-transcriptome sequencing (WTS) to clarify such discrepancies. Among 126 clinically sequenced breast cancers, 15 were selected based on ILC diagnosis or the presence of CDH1 mutation.
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Comparative immunohistochemical expression of TROP2 in brain metastatic and primary tumors

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By You-Na Sung, Jongmin Sim, Harim Oh, Ji Won Lee
| OMICS Publishing Group Verified
*Corresponding Author(s): You-Na Sung, Republic of Korea Ju Won Kim, Division of Oncology/Hematology, Department of Internal medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea, Email: juwon_kim@korea.ac.kr Received: 31-Jul-2025 / Manuscript No. DPO-25-168400 / Editor assigned: 04-Aug-2025 / PreQC No. DPO-25-168400 / Reviewed: 18-Aug-2025 / QC No. DPO-25-168400 / Revised: 25-Aug-2025 / Manuscript No. DPO-25-168400 / Accepted Date:...
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FOXO3a expression is associated with lymph node metastasis and poor disease-free survival in triple-negative breast cancer

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By Abdul Rehman, Yeseul Kim, Hyunsung Kim, Jongmin Sim
| Journal of Clinical Pathology Verified
Aims Forkhead box O (FOXO) transcription factors, consisting of FOXO1, FOXO3a, FOXO4 and FOXO6, are involved in carcinogenesis and tumour progression. Recent studies have suggested that FOXOs act as tumour suppressors in a variety of human cancers. This study investigated the clinicopathological significance of FOXOs in triple-negative breast cancer (TNBC). Methods FOXO protein expressions were assessed by immunohistochemistry in 125 TNBC tissues.
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FOXO3a expression is associated with lymph node metastasis and poor disease-free survival in triple-negative breast cancer

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By Abdul Rehman, Yeseul Kim, Hyunsung Kim, Jongmin Sim
| Journal of Clinical Pathology Verified
Aims Forkhead box O (FOXO) transcription factors, consisting of FOXO1, FOXO3a, FOXO4 and FOXO6, are involved in carcinogenesis and tumour progression. Recent studies have suggested that FOXOs act as tumour suppressors in a variety of human cancers. This study investigated the clinicopathological significance of FOXOs in triple-negative breast cancer (TNBC). Methods FOXO protein expressions were assessed by immunohistochemistry in 125 TNBC tissues.
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