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Jörg Stetefeld

As seen in: Nature, MDPI
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Articles by Jörg Stetefeld

Mechanistic insights into NET1–UNC5B complex formation and Its targeted disruption by NP137 fab and NET1 peptide competitors

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By Monika Gupta, Elena Kitova, Oliver Peters, Scott Legare, Fabian Heide, Natalie Krahn, Ben A. Bailey-Elkin, Serife Akgül, Morgan Brisset, Markus H. Meier, Gay Pauline Padilla-Meier, Abdelrhman Zakaria, Miguel Alcazar, Oleksiy Klymenko, Vesna Stanojlović, Chiara Cabrele, Patrick Mehlen, John Klassen, Manuel Koch, Jörg Stetefeld, Faride Rafiei, Haben Gabir, Candice Harder-Viddal, Roy Roshko
| Nature Verified
Abstract Netrin‑1, a secreted protein initially characterized for its role in axon guidance, has emerged as a critical mediator of cancer progression. Preclinical studies with the anti‑netrin‑1 antibody NP137, which blocks the netrin‑1–UNC5B interaction, have demonstrated reactivation of tumor suppressor functions and sensitization of cancer cells to chemotherapy.
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Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies

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By Fabian Heide, Manuel Koch, Jörg Stetefeld
| MDPI
3. Heparin Mimetics Influence Extracellular Matrix Organization Heparan sulfate is a crucial component for multicellular life, and it interacts with many different signaling proteins and systems. Although heparan sulfate is a very unspecific ligand due to its overall strong negative charge, various heparin mimetics have been developed that constitute different classes, from basic small saccharides to polysulfated oligosaccharides and non-carbohydrate mimetics [,].
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Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance

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By Laura Watson, Kevin Campbell, Jörg Stetefeld, Angela M Sloan, Anthony V Signore
| Nature Genetics Verified
Figure 4 Mean enthalpy of oxygenation (ΔH; kJ mol−1 O ) values of woolly mammoth (blue columns) and Asian elephant (red columns) hemoglobin in the absence and presence of effector molecules.
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