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Abstract Purpose Semi-mechanistic pharmacodynamic (PD) models quantify bacterial dynamics from time-kill (TK) assays, often showing multi-phasic kill and regrowth dynamics. Regrowth is typically captured with two subpopulations with distinct concentration-effect relationships. Since only total bacterial counts are observed, subpopulation dynamics must be inferred, causing identifiability issues, sensitivity to initial estimates, and model-testing burden.
Abstract : Mosquitoes are competent vectors for many important arthropod-borne viruses (arboviruses). In addition to arboviruses, insect-specific viruses (ISV) have also been discovered in mosquitoes. ISVs are viruses that replicate in insect hosts but are unable to infect and replicate in vertebrates. They have been shown to interfere with arbovirus replication in some cases.
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