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B cell development in the bone marrow relies upon an organized tissue structure. Maturing progenitors migrate between several distinct niches and towards the sinusoidal vessels before entering circulation. Microenvironments specific for early developmental stages are provided by stroma expressing CXCL12 (pre-pro-B), IL-7 (pro-B), or Galactin-1 (pre-B); however, the identity of a defined niche for immature B cells remains unclear.
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