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Articles by Joy Burchell
A mucin degrader for cancer therapy - Nature Biotechnology
A new approach to targeting mucins via protein degradation shows promise against cancer. Mucins — barrier glycoproteins that form mucus and other gel-like secretions — have long been a target of interest in oncology, but their thick coating of sugars and diverse functions have defied traditional drug discovery. Although multiple drug candidates that target mucins have been tested in clinical trials, none has shown compelling clinical benefit.
Correction: Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers
This article was republished on August 8, 2017, to replace an earlier version that was published in error. Please download this article again to view the correct version. Citation: Hadjialirezaei S, Picco G, Beatson R, Burchell J, Stokke BT, Sletmoen M (2018) Correction: Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers. PLoS ONE 13(1): e0190814. https://doi.org/10.1371/journal.pone.0190814 Copyright: © 2018 Hadjialirezaei et al.
JARID1/KDM5 demethylases as cancer targets?
Assuming that targeting the KDM5 demethylases in cancer is an aim worth pursuing the question arises as to whether this is feasible without targeting other JmjC dependent demethylases. Most of the efforts directed to identifying demethylase inhibitors have focused on the KDM4 and the KDM5 families as there is considerable data documenting expression of both these families of demethylases in various cancers and their stimulatory effect on growth of cancer cell lines.
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