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Aggressive breast cancers harbor TP53 missense mutations. Tumor cells with TP53 missense mutations exhibit enhanced growth and survival through transcriptional rewiring. To delineate how TP53 mutations in breast cancer contribute to tumorigenesis and progression in vivo, we created a somatic mouse model driven by mammary epithelial cell-specific expression of Trp53 mutations.
Research Article Megan E Conway, Joy M McDaniel, James M Graham, Katrin P. Guillen, Patsy G. Oliver, Stephanie L. Parker, Peibin Yue, James Turkson, Donald J Buchsbaum, Bryan E Welm, Richard M Myers and Katherine E Varley DOI: 10.1158/0008-5472.CAN-20-1379 Abstract Breast cancers are divided into subtypes with different prognoses and treatment responses based on global differences in gene expression.
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