Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with increasing incidence in early-onset patients. The tumour suppressor Adenomatous Polyposis Coli (APC) plays a key role in maintaining epithelial homeostasis, and its mutation is a hallmark of CRC. While most studies have focused on truncating APC mutations, the contribution of C-terminal missense mutations remains poorly understood.
Cancer cells replicate their genomes at a pace that demands rapid pyrimidine de novo synthesis. Dihydroorotate dehydrogenase (DHODH) catalyzes the rate-limiting step of this pathway. For four decades, every inhibitor developed against this enzyme has targeted a single structural feature: the hydrophobic tunnel that guides coenzyme Q to the flavin cofactor. These compounds achieve nanomolar potency, yet none has received oncology approval.
[ES] El cáncer es la principal causa de muerte en todo el mundo, pese a los avances en tratamientos antineoplásicos como la quimioterapia, radioterapia e inmunoterapia. Los inhibidores del citoesqueleto, en concreto ...[+] [ES] El cáncer es la principal causa de muerte en todo el mundo, pese a los avances en tratamientos antineoplásicos como la quimioterapia, radioterapia e inmunoterapia.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
