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Julia E. Gamache

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Articles by Julia E. Gamache

Single cell transcriptomics reveals enrichment of predicted aggregation-prone alpha-synuclein isoforms across synucleinopathies

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By E. Keats Shwab, Daniel C Gingerich, Zhaohui Man, Sapir Margalit, Julia E. Gamache, Geidy E. Serrano, Thomas G Beach, Yuval Ebenstein, Roy Beck, Ornit Chiba-Falek, Webb Pierson, Dean Yona, Asaf Sivan
| Nature Verified
Abstract Alpha-synuclein (α-Syn) is the primary component of Lewy bodies, the pathological hallmark of neurodegenerative synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Dysregulated expression of encoding gene SNCA has been associated with both disorders in short-read sequencing studies. However, such studies do not capture transcript isoform variation.
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Comparative mapping of single‐cell transcriptomic landscapes in neurodegenerative diseases

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By Daniel C Gingerich, Julia E. Gamache, E. Keats Shwab, Zhaohui Man
| Wiley Online Library Verified
1 BACKGROUND Age-associated neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB) exhibit overlapping clinical manifestations of molecular neuropathologies (Figure 1A).
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Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimers disease brains

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By Julia E. Gamache, Julio Barrera, Daniel C Gingerich, Elliot Keats Shwab
| BioRxiv
Abstract Background: The genetic underpinnings of late-onset Alzheimers disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. Since the brain is composed of heterogenous cell subtypes, it is imperative to study the brain on a cell subtype specific level to explore the biological processes underlying LOAD.
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Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice

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By Julia E. Gamache, Lisa Kemper, Elizabeth Steuer, Kailee Leinonen-Wright
| JNeurosci Verified
Research Articles, Neurobiology of Disease Julia E. Gamache, Lisa Kemper, Elizabeth Steuer, Kailee Leinonen-Wright, Jessica M. Choquette, Chris Hlynialuk, Kellie Benzow, Keith A. Vossel, Weiming Xia, Michael D. Koob and Karen H. Ashe Journal of Neuroscience 2 January 2020, 40 (1) 220-236; DOI: https://doi.org/10.1523/JNEUROSCI.1256-19.2019 Abstract Tau is a microtubule-associated protein that becomes dysregulated in a group of neurodegenerative diseases called tauopathies.
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