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Julia Krippner

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Articles by Julia Krippner

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis

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By Samir Abu-Rumeileh, Henning Großkopf, Alexander Mensch, Antonia Ratti, Julian Conrad, Caroline Stapf, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D’Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Ingolf Lachmann, Federico Verde, Markus Otto, Arthur Guthknecht, Dirk Osterloh, Julia Krippner, Jochen Hans Weishaupt
| Nature Verified
Abstract Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed.
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