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1. Introduction MSCs were initially isolated from bone marrow (BM) based on their ability to adhere to plastic culture dishes and to form colony-forming unit fibroblasts (CFU-Fs) [1]. They are capable of self-renewal, produce an extracellular matrix (ECM), and are able to differentiate into multiple cell types [2]. BM-MSCs have been shown to have immunomodulatory properties, controlling inflammation and modifying nearby immune cells [3,4].
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