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Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial Key Points Question Does intravenous tenecteplase before endovascular thrombectomy improve outcomes in patients with basilar artery occlusion who present to thrombectomy-capable centers between 4.5 and 24 hours after stroke onset?
1 Introduction Cerebral small vessel disease (CSVD) represents a complex group of pathological processes primarily affecting the small arteries, arterioles, capillaries, and small veins in the brain. The disease was previously characterized by neuroimaging features including recent small subcortical infarcts, lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces, cerebral microbleeds, and brain atrophy (Wardlaw et al.
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