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Articles by Jun Pyo
CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer’s disease - Alzheimer's Research & Therapy
A total of 616 participants (521 with MCI and 95 with early-stage DAT), aged 60 to 93 years, were recruited from the Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD) project in South Korea [31]. A detailed participant selection process is illustrated in eFigure 1.
Deep learning-based detection of cerebral microbleeds on 2D T2*-weighted GRE MRI: toward ARIA-H risk assessment in Alzheimer’s treatment
Abstract Background: Amyloid-related imaging abnormalities with hemorrhage (ARIA-H) are a key safety concern in anti-amyloid therapies for Alzheimer’s disease, as they are radiologically indistinguishable from cerebral microbleeds (CMBs). Accurate detection of CMBs is therefore essential for both treatment eligibility assessment and post-treatment safety monitoring. However, manual identification on 2D T2*-weighted gradient-recalled echo (GRE) MRI is labor-intensive and subject to variability.
Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups - Alzheimer's Research & Therapy
Participants were consecutively recruited from the Korea-Registries to Overcome dementia and Accelerate Dementia (K-ROAD) project, a multicenter nationwide initiative involving 25 tertiary-care hospitals across South Korea between 2016 and 2024, with Samsung Medical Center (SMC) serving as the core institution.
Correction: Different associations between body mass index and Alzheimer’s markers depending on metabolic health - Alzheimer's Research & Therapy
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea Eun Hye Lee, Heejin Yoo, Young Ju Kim, Bo Kyoung Cheon, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L. Na, Sang Won Seo & Sung Hoon Kang Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Republic of Korea Heejin Yoo, Young Ju Kim, Bo Kyoung Cheon, Hee Jin Kim, Duk L.
Different associations between body mass index and Alzheimer’s markers depending on metabolic health - Alzheimer's Research & Therapy
We recruited a total of 1,772 participants who were either cognitively unimpaired (CU) or had a mild cognitive impairment (MCI) and underwent an Aβ PET scan at the Samsung Medical Center between August 2015 and January 2023. The CU participants were composed of spouses of patients who visited the memory clinic, volunteers who applied for comprehensive dementia evaluation advertised in the paper, and participants who had cognitive complaints.
Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia - Alzheimer's Research & Therapy
We enrolled 2,202 individuals without dementia who attended the memory clinic at Samsung Medical Center (SMC) in South Korea from August 2015 to February 2022 (Fig. 1). Health professionals conducted medical assessments utilizing standardized protocols. Every subject got a comprehensive evaluation that included a neurological examination, cognitive testing, standard blood tests, brain magnetic resonance imaging (MRI), and Aβ [18 F-florbetaben (FBB) or 18 F-flutemetamol (FMM)] PET scans.
Sex-specific relationship between non-alcoholic fatty liver disease and amyloid-β in cognitively unimpaired individuals
Introduction Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease (Younossi et al., 2016) that has detrimental effects on multiple extrahepatic health conditions and liver-related outcomes. NAFLD is closely associated with metabolic syndromes, including diabetes and insulin resistance and complications of metabolic syndromes such as cardiovascular diseases (Gaggini et al., 2013). Thus, NAFLD is considered a hepatic manifestation of metabolic syndrome.
Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population
Introduction Aging population is growing worldwide. By 2050, the world’s population with age over 65 is anticipated to increase to approximately 1.5 billion (United Nations Department of Economic and Social Affairs, 2021). WHO reported in 2012 that about 150 million people would be impacted by dementia by 2050 (Patterson, 2018), which would subsequently increase the total costs of Alzheimer’s disease (AD), the most common cause of dementia, to over $1 trillion (Prince et al., 2015).
Sex differences in the structural rich-club connectivity in patients with Alzheimer’s disease
1. Introduction Alzheimer’s disease (AD), the most common type of dementia in older adults, is characterized by progressive cognitive decline (Ewers et al., 2011; Scheltens et al., 2016). Epidemiological evidence suggests that the prevalence of AD dementia is higher in women than in men (Mazure and Swendsen, 2016).
Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
Alzheimer's Research & Therapy, Mar 2023 This is a preview of a remote PDF: https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-023-01215-8 Kang, Sung Hoon, Liu, Mengting, Park, Gilsoon, Kim, Sharon Y., Lee, Hyejoo, Matloff, William, Zhao, Lu, Yoo, Heejin, Kim, Jun Pyo, Jang, Hyemin, Kim, Hee Jin, Jahanshad, Neda, Oh, Kyumgmi, Koh, Seong-Beom, Na, Duk L., Gallacher, John, Gottesman, Rebecca F., Seo, Sang Won, Kim, Hosung. , Alzheimer's Research & Therapy, 2023, pp.
Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity - Alzheimer's Research & Therapy
Study populations We enrolled CU participants aged ≥ 45 years from the Health Promotion Center of Samsung Medical Center (Seoul, Korea) who underwent a comprehensive health screening exam from September 1, 2008, to October 31, 2019. A total of 8227 eligible candidates underwent a full medical examination, which included cognitive assessment and 3.0-Tesla MRI, including high-resolution T1-weighted MRI, as part of a standard screening for dementia.
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins
Molecular Neurodegeneration, Jan 2023 This is a preview of a remote PDF: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-022-00592-2 Oatman, Stephanie R., Reddy, Joseph S., Quicksall, Zachary, Carrasquillo, Minerva M., Wang, Xue, Liu, Chia-Chen, Yamazaki, Yu, Nguyen, Thuy T., Malphrus, Kimberly, Heckman, Michael, Biswas, Kristi, Nho, Kwangsik, Baker, Matthew, Martens, Yuka A., Zhao, Na, Kim, Jun Pyo, Risacher, Shannon L., Rademakers, Rosa, Saykin, Andrew J.,...
Contribution of clinical information to the predictive performance of plasma β-amyloid levels for amyloid PET positivity
Min Young Chun1, Hyemin Jang1*, Duk L. Na1, Hee Jin Kim1, Jun Pyo Kim1, José Antonio Allué2, Leticia Sarasa2, Sergio Castillo2, María Pascual-Lucas2 and Sang Won Seo1* 1Samsung Medical Center, Sungkyunkwan University, Republic of Korea 2Araclon Biotech, Spain Provisionally accepted: The final, formatted version of the article will be published soon. Background: Early detection of β-amyloid (Aβ) accumulation, a major biomarker for Alzheimer's disease (AD), has become important.
Clinical outcomes of increased focal amyloid uptake in individuals with subthreshold global amyloid levels
Jaeho Kim1, 2, Yeong Sim Choe1, Yuhyun Park1, Yeshin Kim3, Jun Pyo Kim1, Hyemin Jang1, Hee Jin Kim1, Duk L Na1, Soo Jin Cho2, Seung Hwan Moon1* and Sang Won Seo1* 1Samsung Medical Center, Sungkyunkwan University, Republic of Korea 2College of Medicine, Hallym University, Republic of Korea 3Kangwon National University Hospital, Republic of Korea Provisionally accepted: The final, formatted version of the article will be published soon.
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