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Gallstones are one of the most common gastrointestinal diseases, with a prevalence rate of approximately 10–20% in the US population [1]. In recent years, with the improvement of living standards, the morbidity of this disease has been increasing [2]. In terms of the composition of stones, more than 90% of gallstones are mainly composed of cholesterol [3].
In this study, beta nickel hydroxide (?-Ni(OH)2) nanosheet, one of the transition metal oxyhydroxides with two dimensional (2D) structures, was explored as a new fluorescent biosensor platform and applied in constructing optical sensor for bioanalysis. It was found that ?-Ni(OH)2 nanosheet displayed a high fluorescence quenching ability and different affinity toward single- versus double-stranded DNA.
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