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Articles by Junfen Fan
Deep learning-based pathomics reveals renal tubular atrophy with inflammatory cell infiltration as a prognostic marker in IgA nephropathy
Abstract IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. However, there are still many limitations in relying solely on renal pathology to assess the risk IgAN progression. As an emerging technology, pathomics can assist renal pathologists in discovering subvisual features, thereby becoming an important tool for assessing the risk of IgAN progression.
Neurological complications caused by SARS-CoV-2
INTRODUCTION The central nervous system (CNS) and the peripheral nervous system (PNS) make up the human nervous system (1). And the CNS consists of the brain and spinal cord, which integrates and coordinates information and transmits it from neural tissues to various parts of the body. While the PNS consists of the somatic nervous system, autonomic nervous system, enteric nervous system, and other neural tissues outside the CNS (1).
Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke
1 INTRODUCTION Ischemic stroke (IS), which refers to the necrosis and softening of brain tissue caused by cerebral ischemia and hypoxia due to the interruption of blood supply to the brain, is among the main causes of long-term neurological deficits and death among middle-aged and older adults globally.1, 2 Clinically, the main objective of treating ischemic stroke is to restore blood supply.
Long Non-Coding H19 in Lymphocytes: Prognostic Value in Acute Ischemic Stroke Patients
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Development and validation of a nomogram model for predicting unfavorable functional outcomes in ischemic stroke patients after acute phase
1. Introduction Annual data has shown that of the 16 million people who suffer from stroke worldwide, 87% had an ischemic stroke. More than 6 million deaths or disabilities are attributable to stroke, resulting in heavy social, family, and economic burdens. Reduction of disabilities and improvement of the independence of stroke survivors have been the primary goals of rehabilitation (Langhorne et al., 2011).
The emergence of powerful oral anti-COVID-19 drugs in the post-vaccine era
The quest for effective drugs to treat COVID-19 has been a priority since the outbreak of the disease. The clinical application of remdesivir has been greatly restricted by the need for intravenous administration, as well as unstable concentrations in plasma and variable antiviral activity in different organelles. 1 Schooley RT Carlin AF Beadle JR et al. Rethinking remdesivir: synthesis, antiviral activity and pharmacokinetics of oral lipid prodrugs.
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