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Abstract Neutrophil phagocytosis is crucial for combating infections, yet the actin-mediated regulation of vesicular trafficking during late phagosomal maturation remains obscure. Using neutrophils lacking the actin nucleation regulator Wiskott-Aldrich Syndrome Protein and Scar Homolog (WASH), we identify a mechanism linking actin remodeling, lysosomal fusion, and bacterial killing.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.