Highlights • Morphine induced cardioprotective effects. • Nalbuphine did not interfer the cardioprotective effect of morhine. • Nalbuphine could be safely selected or combined with morphine for patients with acute myocardial infraction. Abstract Background When combined with morphine, nalbuphine not only does not affect the analgesic effect but also prevents opioid-induced side effects. The authors investigated whether nalbuphine interferes with morphine-induced cardioprotection in rats.
