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K. A. Scott

As seen in: Wiley Online Library, Diabetes Spectrum, TechTrends
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Articles by K. A. Scott

ATG exposure in T replete transplant for hematological malignancies: Real world analysis from BMT CTN 1202

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By K. A. Scott, Jaap Jan
| TechTrends
In this large ‘real world’ analysis of patients who participated in a prospective registry trial (BMT CTN 1202), we simulated rATG exposures post-HCT using a validated population-PK model (Admiraal et al) [9]. A previously described post-HCT rATG exposure of <30 AUxday/mL correlated with higher OS, faster CD4 + IR and lower relapse probability, compared to higher post-HCT rATG exposures (30-55 and ≥55 AUxd/mL) and patients who did not receive ATG [7, 9, 14, 18, 19].
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Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice

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By K. A. Scott
| Diabetes Spectrum
Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin-producing β-cells. Recent evidence has implicated hybrid insulin peptides (HIPs) as targets of autoreactive CD4 T cells in human T1D patients and as critical autoantigens recognized by diabetogenic T cells in nonobese diabetic (NOD) mice. HIPs form within pancreatic islets through cross-linking reactions between proinsulin fragments and various β-cell peptides.
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Spatially Distributed Modeling of Lake Ice Trends and Distribution in the North Slave Region, NWT, Canada

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By G. Attiah, K. A. Scott, Mechatronics Engineering, H. Kheyrollah Pour
| Wiley Online Library Verified
1 Introduction Warming in Arctic regions since the late 1970s is reported to be almost four times that of the global rate (Rantanen et al., 2022) and has impacted several components of the Earth's cryosphere. As global temperatures continue to rise, there are implications for Northern Canada, whose socioeconomic and cultural systems are centered around ice and snow and where changing lake ice regimes are linked to the natural resource industry (Knoll et al., 2019; Mullan et al., 2017; T. D.
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