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Highlights • Large independent multicentre cohort of patients with anal cancer treated with chemoradiotherapy. • Consistent and independent prognostic effect of p16 and tumour infiltrating lymphocytes demonstrated. • Potential clinical utility in stratifying future treatments in locally advanced disease. Abstract Aims Anal squamous cell carcinomas (ASCC) are strongly associated with human papillomaviruses. Standard of care is chemoradiotherapy at uniform doses with no treatment stratification.
Introduction Oropharyngeal cancer (OPC) is increasing globally and the rate has doubled in the past 15 years in the UK, with clinicians describing it as an ‘epidemic’ [1x[1]Hussein, A.A., Helder, M.N., de Visscher, J.G., Leemans, C.R., Braakhuis, B.J., de Vet, H.C.W. et al. Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: a systematic review. Eur J Cancer.
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