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Abstract An adaptive critic learning control method is developed for wastewater treatment plants to balance water-quality tracking, control effort, and disturbance attenuation. Dissolved oxygen and nitrate concentrations are regulated through aeration and internal recycle flow. The tracking problem is formulated as a continuous-time nonlinear affine \(H_{\infty }\) game with a discounted performance index.
Abstract Proficient mismatch repair colorectal cancer (pMMR-CRC) exhibits resistance to immunotherapy, presenting a significant clinical challenge that must be addressed. Exosomes, which serve as mediators of intercellular communication, play a crucial role in the tumor microenvironment (TME). However, the mechanisms that exosomes regulate tumor immunity in pMMR-CRC need to be fully elucidated.
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