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Kaiya Brand

As seen in: Nature
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Articles by Kaiya Brand

Evidence for anterior cingulate cortex glutathione levels as a biomarker of oxidative stress and antioxidant response in people with bipolar disorder

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By James J. Prisciandaro, Andrew P. Prescot, Saipavitra Murali-Manohar, Jie Zhang, Danyelle M Townsend, Kaiya Brand, Sara Hix, William Mellick, Bryan K. Tolliver, Richard A. E. Edden, Zhiwe Ye
| Nature Verified
Abstract Glutathione (GSH), the brain’s primary antioxidant, confers a critical first line of defense against oxidative-stress-induced cellular damage, with some evidence supporting compensatory upregulation of anterior cingulate cortex (ACC) GSH in bipolar disorder (BD).
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Glutamate- and GABA-targeted drugs for Cc-occurring bipolar and alcohol use disorders: a randomized, double-blind, placebo-controlled, crossover study of N-acetylcysteine, gabapentin, and placebo

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By James J. Prisciandaro, William Mellick, Sara Hix, Bryan K. Tolliver, Raymond F. Anton, Kaiya Brand
| Nature Verified
Abstract Forty percent of people with bipolar disorder (BD) develop alcohol use disorder (AUD), with co-occurring AUD substantially worsening the course of BD. Though efficacious treatments remain elusive, frontal glutamate and GABA dysregulation represent promising targets for intervention.
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