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Abstract <p>BACKGROUND/AIM: Icariin (ICA) is a well-known prenylated flavonoid isolated from Epimedium species and has shown potential antitumor effects in multiple malignancies. However, its effects on human head and neck squamous cell carcinoma (HNSCC) have not yet been elucidated. Therefore, the aim of the present study was to evaluate the antitumor effects of ICA in HNSCC and to explore the associated signaling pathways.
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