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Human invariant NKT cells represent a distinct lymphocyte population that co-express an invariant antigen receptor and NK surface markers. Classic NKT cells express a restricted T cell receptor that recognizes lipids, such as α-Galactosylceramide (α-GalCer), in the context of CD1d.
TCR gene modified T cells in adoptive cell transfer have been shown to have clinical success in treating melanoma and other malignancies. One of the challenges in using TCR gene modified T cells include proper expression of the introduced TCR and function. Mispairing between endogenous and introduced TCR chains allows for the potential of unanticipated off-target reactivity, autoimmunity, and impaired therapeutic efficacy against targeted antigens.
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