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(A) Ten-week-old C57BL/6J mice were fed cuprizone chow for 6 weeks. VC/FKN was infused into the lateral ventricle for 3 days after cuprizone cessation, and mice were returned to normal chow. (B) Representative TEM images of CC sections from VC- and FKN-infused mice. Arrowheads designate well-preserved mitochondria, asterisks abnormal myelin, yellow and blue small and medium diameter axons, respectively, and purple glial fibrillar protein positive regions.
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