Acta Paul Enferm 2023; 36: eAPE01221 Review Article Karina Angélica Tresso , Bruna Nogueira dos Santos , Fernanda Titareli Merizio Martins Braga , Amanda Salles Margatho , Karina Dal Sasso Mendes , Renata Cristina de Campos Pereira Silveira DOI: 10.37689/acta-ape/2023AR012211 Abstract Objective To synthesize knowledge on the use of lock therapy for prevention and treatment of long-term central vascular access devices-associated bloodstream infection in hospitalized adult and elderly patients.