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Karolina Basiak

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Articles by Karolina Basiak

Bone health in myelodysplastic neoplasms: results from the prospective longitudinal BoHemE study

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By Heike Weidner, Elena Tsourdi, Anne Sophie Platzbecker, Martina Rauner, Ulrike Baschant, Maria G. Ledesma-Colunga, Karolina Basiak, Katja Sockel, Ekaterina Balaian, Susann Winter, Klaus H. Metzeler, Katharina Götze, Dominic Brauer, Michael Cross, Marie Schneider, Jörg Lützner, Andreas Roth, Thomas Zerjatke, Gabriele Müller, Uwe Platzbecker, Lorenz C. Hofbauer, Anna Harig, Nicole Modler
| Nature Verified
Abstract Myelodysplastic neoplasms (MDS) are characterized by insufficient hematopoiesis and alterations of the bone marrow microenvironment. However, bone health in MDS has not been evaluated in a prospective, longitudinal setting. Within the Bone and Hematology in Elderly (BoHemE) study, bone mineral density (represented as T-score) and bone-specific serum markers were assessed in patients with MDS (n = 111; 36% female) and age-matched controls (n = 84; 55% female) at baseline and after 3 years.
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Bone marrow transplantation reduces FGF-23 levels and restores bone formation in myelodysplastic neoplasms - Leukemia

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By Heike Weidner, Katja Sockel, Jennifer Rivière, Uwe Platzbecker, Karolina Basiak
| Nature Verified
To the Editor: Myelodysplastic neoplasms (MDS) are hematopoietic stem cell disorders characterized by ineffective hematopoiesis and dysplastic cells in the bone marrow (BM) [1]. In addition, patients with MDS display an increased susceptibility to osteoporosis [2]. Evidence points towards dysregulation in the BM niche that concurrently impairs bone turnover and hematopoiesis. We identified fibroblast growth factor (FGF)-23 as a critical regulator of bone mineralization and erythropoiesis.
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