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Abstract Chemically reactive microbial natural products have enabled therapeutic development1 via their well-established anticancer, antibiotic and antioxidant activities. However, discovery of reactive metabolites is particularly challenging because they may not tolerate traditional bioactivity-guided isolation workflows2.
Abstract While antibiotics mediate chemical warfare among microbes, their roles in the wild extend beyond direct growth inhibition. Some antibiotics have the potential to mediate interference competition by triggering a bacterial stress response that subsequently activates endogenous viruses integrated in bacterial genomes (prophages). Canonically, this activation is regulated by the SOS response upon DNA damage.
Abstract Chemically reactive microbial natural products have enabled therapeutic development via their well-established bioactivities including anticancer, antibiotic, and antioxidant activities. However, discovery of reactive metabolites is particularly challenging because they may not tolerate traditional bioactivity-guided isolation workflows.
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