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Articles by Katja Luck
Role of PER-WDR5 interactions in the mammalian circadian clock
Abstract In the mammalian circadian clock, the transcription factor CLOCK/BMAL1 cycles between an active state recruiting co-activators like MLL1 and repressed states associated with PER1/2 and CRY1/2 clock proteins. The MLL1 complex component WDR5 was also found in a repressive PER complex. Here we show that WDR5 directly binds to the CRY binding domain (CBD) regions of PER1 and PER2.
Variant characterization in the intrinsically disordered human proteome
Abstract Variant effect prediction remains a key challenge in precision medicine. Computational models are increasingly successful in the characterization of missense variants in folded protein regions. However, 37% of all annotated missense variants reside in the 25% of the proteome that is intrinsically disordered, lacking positional sequence conservation and stable structures.
Experimental assessment of AI-based interactome mapping
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Abstract Genotype-phenotype relationships are mediated through intricate networks of physical and functional interactions among macromolecules. Knowledge of the interactome is vital to understand and model genetics and cellular biology.
By Luke Lambourne, Anupama Yadav, Yang Wang, Dae-Kyum Kim, Florent Laval, Kerstin Spirohn-Fitzgerald, Tiziana M. Cafarelli, Istvan Kovacs, Noor Jailkhani, David De Ridder, Katja Luck, Olivia Debnath, Yun Shen, Zhipeng Yang, Miles W. Mee, Mohamed Nabil Helmy, Yves Jacob, Irma Lemmens, Thomas Rolland, Atina G Cote, Marinella Gebbia, Nishka Kishore, Jennifer Knapp, Joseph C. Mellor, Gonen Memisoglu, Jüri Reimand, Jan Tavernier, Michael Cusick, Quan Zhong, Patrick Aloy, Benoit Charloteaux, Frederick Roth, Pascal Falter-Braun, David Hill, Michael Calderwood, Jean-Claude Twizere, Marc Vidal, Alice Desbuleux, Sadie Schlabach, Vladimir V. Botchkarev Jr., Wenting Bian, Gregory G. McClain
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Nature
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Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
Abstract Membrane contact sites (MCS) are essential for organelle communication in eukaryotic cells. Pathogens also establish MCS with host organelles, but the mechanisms underlying these interactions and their role in infection remain poorly understood.
Next-generation large-scale binary protein interaction network for Drosophila melanogaster - Nature Communications
Generation of a large-scale ORF clone resource The entry clone collection was generated from 11,687 BDGP cDNA gold clones40 (see https://www.fruitfly.org/EST/gold_collection.shtml) using attB-tailed PCR. See below for detailed descriptions of primer design and PCR amplification. The PCR products were quality controlled by detection and sizing on agarose gels as follows.
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori
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A reference map of the human protein interactome
New Results View ORCID ProfileKatja Luck, Dae-Kyum Kim, View ORCID ProfileLuke Lambourne, View ORCID ProfileKerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D.
A reference map of the human protein interactome
A reference map of the human protein interactome Katja Luck, Dae Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amelie Dricot, Marinella Gebbia, Madeleine F Hardy, Nishka Kishore, Jennifer J Knapp, Istvan A Kovacs, Irma Lemmens, Miles W Mee, Joseph C Mellor, Carl Pollis, Carles Pons, Aaron D Richardson, Sadie...
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