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Ginkgolic acid obtained as sphingomyelin synthase inhibitor from plant extract library inspired the concept of sphingolipid mimic. Ginkgolic acid derived N-acyl anilines and ginkgolic acid 2-phosphate (GA2P) mimics ceramide and sphingosine 1-phosphate (S1P) respectively in structure and function. GA2P induced phosphorylation of ERK and internalization of S1P receptor 1 (S1P1), indicated potent agonist activity.
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