Abstract To screen therapeutic target genes for AP, MR analysis was conducted, followed by DEG screening, nomogram, GSEA, drug prediction, and molecular docking analyses.529 druggable genes were obtained. After intersection, 36 overlapping genes were identified. Eight overlapping feature genes were screened after PPI and machine learning. Among them, four therapeutic target genes were screened as therapeutic target genes, containing ACVR1C, RASGRP1, RPTOR, and SPTBN1.
