In an open clinical trial for Stage IV melanoma patients, we are testing a promising new therapy in which the patient’s own T cells are genetically engineered with a T cell receptor (TIL 1383I TCR) targeting the melanoma antigen tyrosinase. Included in the TIL 1383I TCR vector is a nonfunctional CD34 marker that can be readily tracked by flow cytometry. These transgenic T cells are infused into the patient with the goals of killing tumor cells and promoting anti-tumor inflammatory responses.
