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The School Committee has met twice over the last few weeks (September 19th and October 3rd). Our own Jackie McCready (Lowell ESL teacher), was nominated by Latinos for Education for exceptional work at the Lowell Elementary School and within the community. She was also honored at the State House in early October.
TCR gene modified T cells in adoptive cell transfer have been shown to have clinical success in treating melanoma and other malignancies. One of the challenges in using TCR gene modified T cells include proper expression of the introduced TCR and function. Mispairing between endogenous and introduced TCR chains allows for the potential of unanticipated off-target reactivity, autoimmunity, and impaired therapeutic efficacy against targeted antigens.
A major obstacle hindering the development of effective immunity against viral infections, their associated disease, and certain cancers is their genomic instability. Accumulation of mutations can alter processing/presentation of antigens recognized by antibodies and T cells leading to immune escape variants. A therapeutic agent that can combat rapidly mutating viral or cancer-associated antigens would be advantageous in providing effective immunity.
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