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Highlights • Oxidative stress plays a critical role in doxorubicin-induced apoptosis of cells. • EIF5A is secreted from cells in response to oxidative stress and induces apoptosis. • Doxorubicin-induced apoptosis of cardiac myocytes is partially mediated by ORAIP. • ORAIP can be a sensitive biomarker for doxorubicin-induced apoptosis. • ORAIP may be a possible therapeutic target for doxorubicin-induced apoptosis.
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