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Chemotherapy with alkylating agents, including temozolomide (TMZ), is the most effective treatment for gliomas, but many patients do not respond to the treatment. Wu et al. now report that high B cell CLL/lymphoma 3 (BCL3) expression promoted resistance to TMZ by activating carbonic anhydrase II. Patients with high BCL3-expressing gliomas showed a poorer response to TMZ and shorter survival than did patients with low BCL3-expressing gliomas.
AZA Treatment Induced Dose-Dependent 5hmC Changes which were Prognostic AZA treatment is known to affect the genome-wide distribution of DNA 5mC and 5hmC modifications, which have been widely used for the diagnosis and prognosis of various types of cancer.[13] To understand the epigenetic modulation effect of AZA treatment, we characterized genome-wide 5hmC profiles for 120 BM and/or PB samples obtained from 40 patients at Day 0 and/or Day 5 through Nano-hmC-Seal.[26] There were only 19...
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