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Abstract Despite studies linking metabolism and cancer, our understanding of the metabolite network that drives metastasis remains incomplete. Through a metabolic RNAi-based screen for cell invasion, we identify alpha-aminoadipate (2-AAA), the intermediate metabolite of aminoadipic semialdehyde synthase (AASS) in the saccharopine pathway, as a common pivotal factor in metastasis of human cancers.
Loading metrics Open Access Peer-reviewed Research Article Kiyoung Eun , Nayoung Hong , Yeon Woo Jeong , Min Gi Park, Seon-Ung Hwang, Yeon I. K. Jeong, Eun Ji Choi, P. Olof Olsson, Woo Suk Hwang, Sang-Hwan Hyun , Hyunggee Kim Kiyoung Eun, Nayoung Hong, Yeon Woo Jeong, Min Gi Park, Seon-Ung Hwang, Yeon I. K. Jeong, Eun Ji Choi, P.
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