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In this large cohort of ICU patients, a higher serum iron quartile was associated with increased 90-day mortality in patients with sepsis. Furthermore, a dose-response analysis indicated that the risk of death on day 90 increased as the quartiles of serum iron levels upon ICU admission increased. In animal models, bacterial proliferation has been shown to be driven by iron sufficiency and suppressed by iron starvation8,9,10.
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