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Articles by Kristian Linnet
Emergence of semi‐synthetic cannabinoids in cannabis products seized in Eastern Denmark over a 6‐year period
Semi-synthetic cannabinoids detected in drug seizures in Eastern Denmark from 2018 to 2023. Hexahydrocannabinol (HHC) was the most frequently observed compound (15% of samples). HHC was largely replaced by other compounds during the study period. 1 INTRODUCTION Cannabis sativa L. is one of the oldest plants cultivated by humans and has been used as food, fibers, medicinally and recreationally [1].
Automated enzymatic hydrolysis of urine samples for improved systematic toxicological analysis of drug‐facilitated sexual assault cases
1 INTRODUCTION Drug-facilitated sexual assaults (DFSA) comprise non-consensual sexual acts towards a victim who is incapacitated or unconscious due the intoxication of drugs and/or alcohol.1-4 Voluntary or involuntary consumption of these substances determines whether the assault is considered proactive or opportunistic. In the proactive approach, the perpetrator administers intoxicating substances covertly or forcefully to the victim with the intention of committing a sexual assault.
Exploring Enzymatic Hydrolysis of Urine Samples for Investigation of Drugs Associated with Drug-Facilitated Sexual Assault
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Evidence of 11-Hydroxy-hexahydrocannabinol and 11-Nor-9-carboxy-hexahydrocannabinol as Novel Human Metabolites of Δ9-Tetrahydrocannabinol
1. Introduction (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC, Figure 1) is the primary psychoactive compound in the Cannabis sativa plant. The metabolism of Δ9-THC has been studied in several species, including humans, since the 1970s, and the compound has been demonstrated to undergo extensive phase I and II metabolism [1]. Known phase I reactions include both aliphatic and allylic hydroxylations, with further oxidation to carbonyl compounds and carboxylic acids.
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