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1 Introduction Bone regeneration can be enhanced by the combined use of grafting materials and biologic mediators. Among these, bone morphogenetic proteins (BMPs) have emerged as a viable strategy, as they stimulate mesenchymal progenitor cell migration and osteoblast differentiation (Galarraga-Vinueza et al. 2024). First described by Urist in 1965 (Urist 1965) and later molecularly identified by Wozney and colleagues (Wozney et al.
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