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1. Introduction Click to copy section linkSection link copied! Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder. Symptoms of the condition range from mild to severe, with the most severely affected individuals enduring ongoing fatigue, frequent pain, and postexertional malaise (PEM), which is the exacerbation and onset of new symptoms after exertion, both physical and mental.
Introduction Many neuropsychiatric disorders are accompanied by abnormal regulation of the immune system, while many immune system disorders are influenced by the central nervous system (CNS) (Gibney and Drexhage, 2013; Kipnis, 2016; Dantzer, 2018; Reardon et al., 2018).
Glutamate and nicotinamide adenine dinucleotide (NAD+) have been implicated in neuronal development and several types of cancer. The kynurenine pathway of tryptophan metabolism includes quinolinic acid (QA) which is both a selective agonist at N-methyl-D-aspartate (NMDA) receptors and also a precursor for the formation of NAD+. The effect of QA on cell survival and differentiation has therefore been examined on SH-SY5Y human neuroblastoma cells.
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