This study aims to examine the changing practices of exclusive enteral nutrition (EEN) in paediatric Crohn’s disease (CD) including the influence of the 2021 ECCO-ESPGHAN guidelines and the COVID-19 pandemic. We analysed a prospectively identified cohort of newly diagnosed CD patients in two paediatric regional centres between 01/01/15 and 30/06/22. Data were retrospectively collected from electronic medical records. CD patients who received EEN were divided into biannual epochs for analysis.