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Articles by L K Meyer
P46 How much of the improvement in functional outcome after successful recanalization is explained by follow-up infarct volume reduction?
Abstract Introduction Mechanical thrombectomy (MT) has been shown to improve functional outcome in patients with anterior circulation stroke. However, previous works suggest only limited explanatory effect of infarct volume reduction on outcome in patients undergoing MT vs. standard medical care1. Aim of the study The amount of improvement of functional outcome explained by follow-up infarct volume reduction after successful recanalization has not been investigated in detail.
O21 Effect of anesthetic strategy on procedural and clinical outcomes in primary distal medium-vessel occlusion stroke: results from the TOPMOST Registry | Journal of NeuroInterventional Surgery
Abstract Introduction Numerous questions regarding procedural details of thrombectomy for distal medium-vessel occlusions (DMVO) remain unanswered, including the optimal anesthetic strategy.1 Aim of study This analysis was performed to assess the effect of anesthetic strategies on outcomes and safety in patients undergoing distal thrombectomy.
P83 The relationship of functional outcome after mechanical thrombectomy and serum glucose is partially mediated by edema formation
Abstract Introduction High blood glucose was shown to be associated with worse clinical outcome and increased edema formation in patient with acute stroke undergoing mechanical thrombectomy.1 A better understanding of the pathophysiological pathways and a quantification of their effects might support targeted therapeutic approaches. Aim of the Study To quantify the amount of outcome deterioration explained by edema formation due to high blood glucose.
O14 Benefit of thrombectomy in patients with extensive baseline stroke depends on early ischemic lesion water uptake: results from the I-LAST study
Abstract Background The benefit of mechanical thrombectomy (MT) in ischemic stroke patients with ASPECTS<6 is still uncertain. ASPECTS rating is based on the presence of relative hypoattenuation, however the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered as imaging biomarker in stroke triage. We hypothesized that quantitative lesion water uptake in admission-CT mediates the effect of thrombectomy on functional outcome in low ASPECTS patients.
P93 Flow restoration in large vessel occlusion is associated with systemic blood pressure reduction
Abstract Introduction Blood pressure management during mechanical recanalization is known to influence the infarct core size and therefore clinical outcome. Aim of study We investigated the impact of flow restoration on the systemic blood pressure during thrombectomy. Methods From June 2016 to January 2018 all patients with large vessel occlusion in the anterior circulation undergoing mechanical thrombectomy were screened.
P82 Thrombectomy for primary isolated distal anterior cerebral artery occlusion stroke
Abstract Introduction Distal medium-vessel occlusions (DMVO) stroke represents a possible next frontier of endovascular stroke treatment. However, evidence suggesting a possible benefit remains sparse, especially in the anterior cerebral artery (ACA).1 2 Aim of study To investigate clinical and safety outcomes of primary isolated ACA occlusion stroke treated with thrombectomy.
P91 Direct thrombectomy versus intravenous bridging - the benefit of alteplase depends on ASPECTS
Abstract Introduction and aim of this study Baseline variables could be used to guide the administration of additional intravenous alteplase (IVT) before mechanical thrombectomy (MT). The aim of this study was todetermine how baseline imaging and demographic parameters modify the effect of IVT on clinical outcomes. We hypothesized that the extent of early ischemic changes modify the effect of IVT on functional outcomes in stroke patients undergoing MT.
JAK|[sol]|STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
The genetic heterogeneity of T-ALL has precluded the use of genetic alterations for risk-based stratification. We reasoned that these diverse genetic lesions might converge on a more limited set of biochemical abnormalities that could be used to identify subsets of T-ALLs that share common mechanisms of chemotherapy resistance. We tested this hypothesis by assessing drug responses in vitro using phosphoflow cytometry in primary T-ALL cells.
Leukemia - Abstract of article: JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
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